March 3, 2026Open Access

Perinatal exposure to metal mixtures disrupts neuronal function and behavior

Key Points

Juvenile mice exposed to the PACC metal mixture show impaired cognition and increased anxiety-like behavior.
Specifically, cognition decline and anxiety-like behavior increase were observed following perinatal exposure to metals.
This analysis examines the effects of perinatal exposure to metal mixtures on neuronal function in juvenile mice.
Results suggest potential long-term impacts of heavy metal exposure during early development on behavior and cognition.

Abstract

Our findings suggest that perinatal exposure to the PACC metal mixture impairs cognition, increases anxiety-like behavior, and alters neuronal function in specific brain regions of juvenile mice, leading to disruption in neuronal function and behavior. Further studies are needed to provide mechanistic insight into how perinatal heavy metal exposure affects neuronal development.

Perinatal exposure to metal mixtures disrupts neuronal function and behavior

Key Points

Abstract

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