Hyaluronic acid-coated Poly(L-lactide-co-1,3-trimethylene carbonate) modulate early cellular-scaffold interactions and osteogenic potential: a comprehensive in vitro and in vivo evaluation using mesenchymal stromal cells

Key Points

• HA coating significantly improves scaffold hydrophilicity and enhances cell adhesion, promoting osteogenic potential.
• Key metrics indicate that HA-coated scaffolds increase osteogenic signaling and cellular engagement in early stages.
• Observational analysis across in vitro and in vivo settings reveals the influence of scaffold properties on long-term outcomes.
• These findings suggest the potential for HA-coated scaffolds in dental biofabrication and bone regeneration, warranting further exploration.