Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models

Key Points

• Successful gene editing resulted in corrected mutations associated with congenital ichthyosis, improving skin morphology.
• The approach utilized lipid nanoparticles to deliver gene editing components effectively into targeted skin cells.
• Assessment of outcomes was conducted through in situ gene editing in human skin models, ensuring direct relevance to human health.
• This innovative method may enable future therapeutic strategies for congenital skin disorders, pending further validation.