Zn‐Doped Hydroxyapatite Nanorods With Dual Antibacterial‐Osteogenic Functions for Periodontal Regeneration

ABSTRACT Alveolar bone deterioration is a significant consequence of periodontal disease, often resulting from persistent inflammation that damages both soft and hard tissues, ultimately leading to tooth loss. Traditional approaches for regenerating alveolar bone defects remain limited by suboptimal efficacy and biocompatibility. To address these challenges, this study aimed to develop and evaluate zincdoped hydroxyapatite nanorods (Zn‐HAp NRs) with osteogenic and antibacterial potential for alveolar bone regeneration. Zn‐HAp NRs were synthesized via a one‐step in situ mineralization process. The in vitro findings demonstrated that Zn‐HAp NRs significantly promoted osteogenic differentiation. Additionally, the material exhibited notable antibacterial properties, supporting its potential as a dual‐functional agent capable of enhancing bone regeneration while mitigating infection risks. Zn‐HAp NRs represent a promising biomaterial for alveolar bone regeneration, combining effective osteogenic induction with antibacterial performance. Their synthesis via a facile one‐step process further supports the feasibility of scaling up production for clinical applications. Importantly, as the present evidence is primarily based on in vitro experiments, further in vivo investigations are warranted to validate the regenerative efficacy and safety of Zn‐HAp NRs in the complex periodontal microenvironment.