Tumor neoantigen gene C7orf50 remodels the immune microenvironment by recruiting tumor-associated macrophages to promote hepatocellular carcinoma progression and lung metastasis

Key Points

• C7orf50 mediates the immune microenvironment remodeling, promoting HCC progression and lung metastasis, and indicates potential for targeted therapies.
• High expression levels of C7orf50, PAI-1, and CD68 serve as independent prognostic markers for HCC outcomes.
• This analysis examines molecular pathways, focusing on the NF-κB/PAI-1 pathway and its role in tumor-associated macrophage recruitment.
• Findings underscore the potential of C7orf50-related neoantigens in precision medicine and immunotherapy for HCC, paving the way for further research.