March 3, 2026Open Access

lncRNA SND1-IT1/miR-494-3p regulation in ox-LDL-induced endothelial cell injury: novel insights into coronary heart disease pathogenesis and diagnostic biomarkers

Key Points

Altered expression of lncRNA SND1-IT1 and miR-494-3p associates with coronary heart disease risk.
The regulation of ox-LDL-induced endothelial cell injury involves the interaction between miR-494-3p and ZBTB20.
Analysis involved endothelial cells exposed to ox-LDL to mimic conditions in coronary heart disease.
These findings suggest novel biomarkers for assessing coronary heart disease and its pathogenesis.

Abstract

Altered SND1-IT1 and miR-494-3p expressions in CHD patients show potential as biomarkers for CHD risk assessment. SND1-IT1 may regulate ox-LDL-induced damage in HUVECs by modulating the interaction between miR-494-3p and ZBTB20.

lncRNA SND1-IT1/miR-494-3p regulation in ox-LDL-induced endothelial cell injury: novel insights into coronary heart disease pathogenesis and diagnostic biomarkers

Key Points

Abstract

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