ANCA-associated vasculitis following sotatercept initiation in a patient with heritable pulmonary arterial hypertension and previously silent eosinophilic granulomatosis with polyangiitis: a case report

Key Points

• Sotatercept initiation coincided with the emergence of eosinophilic granulomatosis with polyangiitis (EGPA), indicating a potential link.
• The relationship noted here implies that sotatercept can modulate immune responses, unmasking latent autoimmune conditions.
• This observational case report evaluates the impact of sotatercept on the TGF-β pathway, potentially linking it to autoimmune disease flare-ups.
• Further investigation is needed to clarify the underlying immunomodulatory mechanisms associated with sotatercept in similar cases.

Abstract