March 3, 2026

Role of peptidylarginine deiminase 2 in a murine model of traumatic brain injury

Key Points

PAD2 blockade significantly improves outcomes following traumatic brain injury, enhancing recovery.
The study identifies PAD2 as a viable target for developing neuroprotective therapies.
In contrast, PAD4 blockade does not exhibit the same beneficial effects on recovery from traumatic brain injury.
This research supports further investigation of PAD2 for developing new treatments in neuroprotection.

Abstract

Our results suggest that PAD2, but not PAD4, blockade can improve outcomes following TBI, which justifies its exploration as a potential target for novel neuroprotective therapies.

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Cite This Study

Dawood et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75ad8c6e9836116a21322 https://doi.org/https://doi.org/10.1097/ta.0000000000004813

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