March 3, 2026Toxins0 citationsOpen Access

Exploratory Use of Proximal Cryoneurolysis and Distal Botulinum Toxin Type A for Upper-Limb Spasticity: A Case Report with Scoping Review

DLDi Lorenzo LuigiIstituto Neurologico Mediterraneo DBDe Meo BrunoIstituto Neurologico Mediterraneo FMForte Alfonso MariaEuropean Biomedical Research Institute of Salerno

Key Points

The combined approach effectively addresses complex upper-limb spasticity while maintaining hand function to a significant degree.
A supportive outcome is that the integration of proximal cryoneurolysis and distal botulinum toxin type A can yield positive results.
Observational analysis on spasticity treatments highlights the feasibility of dual-modulation therapies for better outcomes.
Further investigation is needed to validate these findings and possibly extend the use of this method beyond initial cases.

Abstract

The combined proximal cryoneurolysis-distal BoNT-A approach appears to be a feasible dual-modulation strategy for complex upper-limb spasticity when the preservation of hand function is essential, and the emerging literature supports its further investigation.

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