Kaempferol inhibits osteoclast differentiation and bone resorption by targeting the TNF-α/NF-κB and SRC/PI3K/AKT signaling pathways

Key Points

• Kaempferol reduces bone resorption by targeting osteoclast differentiation, impacting calcium homeostasis in bone.
• Bone resorption decreased by 50% when treated with kaempferol under TNF-α stimulation.
• Analysis of molecular pathways involved highlights the TNF-α/NF-κB and SRC/PI3K/AKT signaling pathways as key mediators.
• These findings suggest potential for kaempferol in treating bone diseases related to excessive bone resorption.