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March 3, 2026
Open Access
Metabolically regulated proteasome supramolecular organization in situ
XT
Xiaomeng Tang
Max Planck Institute of Experimental Medicine
LQ
Lu Qu
Max Planck Institute for Biophysical Chemistry
FW
Florian Wilfling
Max Planck Institute of Biophysics
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Key Points
Proteasome organization is influenced by metabolic states within cells, demonstrating dynamic regulation.
Key evidence includes visual mapping of proteasome structures under varying metabolic conditions.
Analysis of cellular models shows how metabolic changes affect proteasome function and organization.
These findings highlight the need for further exploration of metabolically regulated pathways in protein degradation.
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Metabolically regulated proteasome supramolecular organization in situ | Synapse
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Tang et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b77c6e9836116a22d35
https://doi.org/https://doi.org/10.1016/j.cell.2025.12.035