March 3, 2026Immunity Inflammation and Disease0 citationsOpen Access

Kaempferitrin Attenuates Lipopolysaccharide‐Induced Cardiac Dysfunction Through Suppression of the NF‐κB/NLRP3 Signaling Pathway

HKHongyu KuangChongqing Medical University QLQiang LiChildren's Hospital of Chongqing Medical University MCMin ChenChildren's Hospital of Chongqing Medical University

Key Points

Cardiac dysfunction improves significantly with kaempferitrin treatment, enhancing heart function.
The study observed a reduction in left ventricular remodeling, indicating improved cardiac health.

Structured PICO

Population

LPS-induced cardiac dysfunction model

Intervention

Kaempferitrin (Kae)

Outcome

Left ventricular remodeling and cardiac dysfunctionsurrogate

Kaempferitrin demonstrates cardioprotective effects against LPS-induced cardiac dysfunction in a preclinical model by targeting the NF-κB/NLRP3/pyroptosis pathway.

Abstract

This study confirms that Kae alleviates LPS-induced left ventricular remodeling and cardiac dysfunction by suppressing the NF-κB/NLRP3/pyroptosis pathway.

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