March 3, 2026Open Access

Breast Cancer Reveals Latent BMPR2 -Related Susceptibility to Pulmonary Hypertension

Key Points

Pulmonary hypertension may arise due to defective bmpr2 signaling influenced by breast cancer.
A reciprocal association reveals that breast cancer can expose underlying susceptibility to pulmonary hypertension.
Analysis emphasizes tumor-associated inflammation as a significant factor in this association.
The findings suggest a need for better monitoring of at-risk populations with breast cancer.

Abstract

These findings identify a reciprocal association between breast cancer and PAH mediated by defective BMPR2 signaling and tumor-associated inflammation. Breast cancer may act as a "second hit," unmasking BMPR2-related susceptibility to PAH, underscoring BMPR2 as a shared molecular vulnerability with implications for surveillance of at-risk populations.

Breast Cancer Reveals Latent BMPR2 -Related Susceptibility to Pulmonary Hypertension

Key Points

Abstract

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