March 3, 2026Open Access

PANoptosis-related genes in rheumatoid arthritis synovial tissue: screening, validation, and functional implications

Key Points

Key panoptosis markers IL-18 and NLRP3 are implicated in synovial hyperplasia.
Caspase-1 and Caspase-3 function could significantly impact immune cell behavior in RA.
Analysis of synovial tissue reveals an immune cell imbalance contributing to disease pathology.
Findings suggest that targeting these markers could lead to new treatment strategies for rheumatoid arthritis.

Abstract

During the pathogenesis of RA, the key PANoptosis markers (IL-18, NLRP3, GBP1, TNFSF10, Bax, Bcl-2, Caspase-1, and Caspase-3) are involved in invasive synovial hyperplasia. The characteristic immune cell imbalance in RA provides conditions for these key PANoptosis markers to regulate immune cell functions, and it is an important basis for the pathological changes of joint synovial hyperplasia in RA.

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Cite This Study

Lu et al. (Wed,) studied this question.

synapsesocial.com/papers/69a75befc6e9836116a24297 https://doi.org/https://doi.org/10.3389/fimmu.2026.1737366

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