Stage-specific temporal associations between body mass index trajectories and Alzheimer’s disease pathologies

Key Points

• Body mass index trajectories significantly correlate with the progression of Alzheimer's disease pathologies and cognitive decline.
• The analysis showed a clear link between higher body mass index at different stages and increased Alzheimer's pathologies such as amyloid plaques.
• Observational analysis across various stages indicates that monitoring body mass index could provide insights into Alzheimer's disease risk.
• These findings may highlight the need for early dietary interventions to potentially mitigate Alzheimer's disease progression.