Inhibition of Castration-Sensitive LNCaP, Castration-Resistant TRAMP-C2, and Bone-Metastatic C4-2B Prostate Cancer Cell Growth by an Alpha-Tomatine Tomato Extract: In Vitro and In Vivo Study

Key Points

• Cell growth inhibition was observed in castration-sensitive and resistant prostate cancer cells, highlighting treatment possibilities.
• Alpha-tomatine from tomato extract reduced the growth of prostate cancer cells, with significant effects noted between the types tested.
• In vitro and in vivo assessments showed a marked decrease in tumor growth due to alpha-tomatine treatment, validated across different cell lines.
• Potential implications include the use of alpha-tomatine as a novel therapeutic intervention, yet further research is required.