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March 3, 2026
Galangin mitigates letrozole-induced polycystic ovary syndrome in rats by restoring PI3K/pAKT/PTEN signaling
LB
Lenah S. Binmahfouz
King Abdulaziz University
AB
Amina M. Bagher
NB
Najlaa S. Binmahfouz
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Key Points
Galangin significantly reduces the severity of polycystic ovary syndrome in the rat model, restoring normal ovary function.
The PI3K/AKT/PTEN signaling pathway shows notable improvement with treatment, indicating effective intervention.
Experimental analysis using letrozole-induced rats highlights the potential role of galangin as a therapeutic agent.
Further exploration is needed on galangin's effectiveness in larger, diverse populations to confirm these results.
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Galangin mitigates letrozole-induced polycystic ovary syndrome in rats by restoring PI3K/pAKT/PTEN signaling | Synapse
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Binmahfouz et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75c8ac6e9836116a257e5
https://doi.org/https://doi.org/10.1007/s00210-026-05045-x