Development and Characterization of a Rat Model of Blast Polytrauma and Hemorrhagic Shock for Evaluating Innate Immunotherapies During Prolonged Damage Control Resuscitation

Key Points

• This model successfully replicates inflammation-driven multi-organ dysfunction syndrome.
• Key features include the assessment of innate immunotherapies during prolonged damage control resuscitation.
• Observational model analysis highlights the therapeutic potential for addressing blast-induced trauma.
• Findings underscore the relevance of this model in studying TH-related immunopathology.