Identification of a novel chalcone derivative as ferroptosis inducer through targeting TrxR in prostate cancer

Key Points

• The novel chalcone derivative induces ferroptosis in prostate cancer cells, enhancing treatment options.
• Key findings show a significant reduction in tumor cell viability by 30% after treatment with the derivative.
• Assessment of the mechanism reveals targeting of thioredoxin reductase, crucial for oxidative stress regulation.
• These findings support further investigation into chalcone derivatives as potential cancer therapies.