Pesticide abuse poses a serious threat to food security and public health, while the scientific design of delivery systems is an important strategy for improving the precision of pesticide application. This study reports the development of a pesticide delivery platform using organogels to enhance stability in pest control and improve the simplicity and versatility of pesticide loading processes. The results show that the formation of the gel network occurs simultaneously with pesticide loading, achieving efficient pesticide capture at the molecular level. Meanwhile, the molecular configuration of the network can be flexibly tuned to adjust the mechanical strength of pesticide-loaded organogels (PLOs), thereby enhancing their adaptability to biological interfaces. By constructing pesticide-loaded organogel formulations (PLOFs) within micro-scale reaction spaces, the system exhibits high topological affinity and controlled release behavior at biological interfaces in crop protection scenarios. Moreover, PLOFs demonstrate greater stability under climatic stress compared with traditional formulations. The study systematically elucidates the binding and release mechanisms between PLOs networks and pesticide molecules, and evaluates the efficacy and stability of PLOFs in various crop protection applications. This work highlights the great potential of PLOFs in enhancing pesticide utilization and provides a new perspective for the design of functional pesticide delivery systems.
Wang et al. (Wed,) studied this question.