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Lysosomes as hubs of metabolic sensing and cellular homeostasis | Synapse
March 3, 2026
Lysosomes as hubs of metabolic sensing and cellular homeostasis
AJ
Apurva Jain
Pacific University Oregon
RZ
Roberto Zoncu
Key Points
Lysosomes integrate various signaling pathways, influencing metabolic sensing and homeostasis.
The findings suggest a multifaceted role of lysosomes beyond waste disposal, impacting cellular health.
This analysis monitors lysosomal function correlating it with metabolic activity across various cell types.
These insights may enable new therapeutic strategies targeting lysosomal dysfunction in metabolic disorders.
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Jain et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75d45c6e9836116a2705c
https://doi.org/https://doi.org/10.1016/j.molcel.2026.01.011