Xinfeng capsule improves hyperinflammation-associated hypercoagulability and self-perception in osteoarthritis by regulating KLF4 through METTL14-mediated m6A modification of lncRNA MEG3

Key Points

• Xinfeng capsule improves self-perception and hypercoagulability in osteoarthritis patients, addressing key symptoms.
• The therapy significantly upregulates lncRNA MEG3 and KLF4 expression, influencing inflammation and coagulation.
• Assessment via mechanistic analysis reveals the role of METTL14-mediated m6A modification on lncRNA MEG3.
• Findings highlight the need for further exploration of Xinfeng capsule's potential in broader populations affected by osteoarthritis.