Xerostomia is a common condition that often affects patients undergoing radiotherapy for head and neck cancers. The condition arises primarily due to damage to the salivary glands, leading to a signifi-cant reduction in saliva production. This not only impacts oral health but also diminishes the quality of life for patients, making it essential to explore effective treatment options. One such innovation is the Sal-iPen electrostimulator, a device designed to stimulate salivary gland function. Several clinical trials have investigated the efficacy of the SaliPen electrostimulator in patients suffering from xerostomia due to ra-diotherapy. When the SaliPen is activated, the control unit generates low-frequency electrical impulses. These impulses are typically in the range of 1 to 100 Hz, which is optimal for stimulating the salivary glands without causing discomfort to the user. The generated impulses are transmitted through the elec-trodes to the oral mucosa. The design of the electrodes ensures that the electrical current penetrates the tissue effectively, reaching the nerve endings associated with the salivary glands. The electrical impulses stimulate the afferent nerve fibers in the oral mucosa, particularly those linked to the parasympathetic nervous system. As a result of the electrical stimulation, neurotransmitters such as acetylcholine are re-leased at the synapses of the salivary glands. Acetylcholine is a key neurotransmitter in the stimulation of saliva secretion, activating the glandular cells responsible for producing saliva. The activation of the sali-vary glands leads to an increase in saliva production. The SaliPen effectively enhances the function of the remaining viable salivary tissue, allowing patients to experience relief from the symptoms of xerostomia. As further research elucidates its benefits and optimizes treatment protocols, the SaliPen may become a standard element in the care of patients suffering from the debilitating effects of dry mouth. As healthcare continues to evolve, innovations like the SaliPen demonstrate the potential for improved outcomes in the management of complex postradiation-related symptoms. Key words: electrostimulation, xerostomia, radiotherapy, salivary glands, head and neck cancer
Rogoleva et al. (Mon,) studied this question.