Quercetin inhibits glycolysis and tumor progression in a cell line-dependent manner, involving PI3K/AKT signaling predominantly in HOS cells

Key Points

• In HOS cells, quercetin treatment leads to significant inhibition of glycolysis and tumor progression.
• An approximate 50% reduction in tumor growth was observed following quercetin treatment over 72 hours.
• Assessment of cellular mechanisms shows involvement of the PI3K/AKT signaling pathway in mediating effects.
• These findings highlight the need for further exploration of quercetin as a specific anti-cancer therapy.