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March 3, 2026
4,4′-dimethoxychalcone exerts neuroprotective effects in Alzheimer's disease mice by activating the Keap1/Nrf2 signaling pathway
SM
Shanshan Ma
QW
Qianqian Wang
WY
Wenzhi Yang
BGI Group (China)
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Key Points
Neuroprotection was observed through activation of the keap1/nrf2 signaling pathway, reducing oxidative stress.
Mice treated with 4,4′-dimethoxychalcone showed significant improvements in cognitive function and behavior.
Observational analysis across a mouse model of Alzheimer's disease evaluated the effects of 4,4′-dimethoxychalcone.
Highlighting the potential for new treatment strategies targeting oxidative stress in Alzheimer's disease.],
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Ma et al. (Thu,) studied this question.
synapsesocial.com/papers/69a75e05c6e9836116a285c3
https://doi.org/https://doi.org/10.1016/j.ejphar.2026.178617
4,4′-dimetoxichalcone exerce efeitos neuroprotetores em camundongos com doença de Alzheimer ao ativar a via de sinalização Keap1/Nrf2 | Synapse