March 3, 2026Open Access

GNAL-driven calcium signaling reshapes the spatiotemporal immune landscape in ER+ breast cancer: causal insights and prognostic implications

Key Points

Calcium signaling reshapes the immune landscape in ER+ breast cancer, indicating significant changes in disease progression.
A multi-omics risk model identifies GNAL as a robust prognostic biomarker with clinical implications.
Analysis illustrates how stem-like cell differentiation is influenced by GNAL-mediated pathways in the tumor microenvironment.
Highlights the potential of targeting GNAL for precision immunotherapy, supporting the need for tailored treatment strategies.

Abstract

GNAL regulates the spatiotemporal immune remodeling of ER+ breast cancer via calcium signaling and stem-like cell differentiation. The multi-omics risk model offers clinical prognostic value and highlights GNAL as a potential target for precision immunotherapy.

GNAL-driven calcium signaling reshapes the spatiotemporal immune landscape in ER+ breast cancer: causal insights and prognostic implications

Key Points

Abstract

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