March 3, 2026Open Access

A venom fraction from the Philippine tarantula (Orphnaecus sp.) reveals low-molecular-weight compounds that potentiate drug-like neurobehavioral responses in Danio rerio

Key Points

Venom fractions induce pronounced neurobehavioral effects, including hyperactivity and anxiolytic-like responses.
Key findings suggest potential antinociceptive properties linked to low-molecular-weight compounds in the venom.
Assessment of venom effects was conducted using Danio rerio, a model widely used in neurobehavioral studies.
These findings highlight therapeutic possibilities for drug development based on tarantula venom components.

Abstract

Overall, the fractions of venom from the Orphnaecus tarantula species appear to induce distinct neurobehavioral effects, which may include hyperactivity, anxiolytic-like responses, and potential antinociceptive properties.

A venom fraction from the Philippine tarantula (Orphnaecus sp.) reveals low-molecular-weight compounds that potentiate drug-like neurobehavioral responses in Danio rerio

Key Points

Abstract

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