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March 3, 2026
Hyodeoxycholic acid in Arisaema Cum Bile can alleviate pentylenetetrazol-induced epilepsy by activating p53/Nrf2/GPX4 to inhibit ferroptosis
XQ
Xiaoyang Qu
LC
LiJuan Chen
JH
Jianghua He
Beijing University of Chinese Medicine
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Key Points
Hyodeoxycholic acid significantly reduces seizure frequency in the model of epilepsy, targeting ferroptosis pathways.
Activation of the p53/Nrf2/GPX4 pathway enhances cellular defense mechanisms against oxidative stress.
Analysis of pentylenetetrazol-induced epilepsy indicates potential benefits in ferroptosis inhibition.
Findings may lead to new therapeutic strategies for managing epilepsy and neurodegenerative diseases.
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Hyodeoxycholic acid in Arisaema Cum Bile can alleviate pentylenetetrazol-induced epilepsy by activating p53/Nrf2/GPX4 to inhibit ferroptosis | Synapse
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Qu et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75eb3c6e9836116a298f0
https://doi.org/https://doi.org/10.1016/j.phymed.2026.157907