D-Methionine Improves Spatial Navigation and Attenuates Oxidative Stress and Amyloid Pathology in a Sex-Specific Manner

Key Points

• D-Methionine treatment significantly improves spatial navigation abilities.
• In female APP^NL-F mice, oxidative stress levels drop remarkably after D-Met administration.
• Assessment of the metabolic modulator highlights its role in enhancing microglial function.
• Findings indicate the need for sex-specific approaches in treatments for amyloid-related conditions.