Targeting senescent cells in aged adipose tissue induced by ovarian cancer with the NF-κB inhibitor quercetin and resveratrol impedes the growth and metastasis of ovarian cancer

Key Points

• Quercetin and resveratrol effectively reduce ovarian cancer growth and metastasis, improving treatment outcomes.
• Experiments demonstrated a marked decrease in cancer cell spread in aged adipose tissue when NF-κB was inhibited.
• Intervention involved targeting senescent cells in ovarian cancer models, focusing on the role of aging in tumor development.
• Findings may help formulate new strategies for cancer therapy, particularly in older populations.