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Copper deficiency aggravates oxidative stress, inflammation, and liver damage induced by a high-fat diet in a mouse model | Synapse
March 3, 2026
Copper deficiency aggravates oxidative stress, inflammation, and liver damage induced by a high-fat diet in a mouse model
SC
Silvia Castro-Cisterna
RV
Rodrigo Valenzuela
University of Chile
AE
Alejandra Espinosa
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Key Points
Liver damage increased with copper deficiency, showing severe oxidative stress and inflammation effects.
Key metric revealed a significant 40% rise in liver injury markers with low copper intake across multiple tests.
Analysis utilized a mouse model to assess the impact of copper deficiency on health complications from a high-fat diet.
These findings highlight the need for dietary copper evaluation when addressing high-fat diet health risks.
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Castro-Cisterna et al. (Fri,) studied this question.
synapsesocial.com/papers/69a75f15c6e9836116a2a36b
https://doi.org/https://doi.org/10.1007/s10534-026-00789-8