Multimodal AI model (PATH-ORACLE) integrates histology and transcriptomics to predict stage I LUAD recurrencePATH-ORACLE outperforms IASLC grading and transcriptomic or image-based models aloneModel achieves >85% recurrence prediction accuracy across independent international cohortsPATH-ORACLE refines risk stratification within both stage IA and IB lung adenocarcinomaBiomarker may guide adjuvant therapy selection and surveillance in early-stage disease.
Kilim et al. (Fri,) studied this question.