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TFAP2A facilitates aerobic glycolysis and metastasis of pancreatic cancer via IGF2BP2-mediated LDHA m6A modification | Synapse
March 3, 2026
TFAP2A facilitates aerobic glycolysis and metastasis of pancreatic cancer via IGF2BP2-mediated LDHA m6A modification
ZX
Zhiying Xu
XZ
Xingyang Zhong
ZY
Zhishi Yang
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Key Points
Metastasis is significantly enhanced by TFAP2A activity in pancreatic cancer cells, indicating a crucial role in disease progression.
Elevated levels of LDHA m6A modification are closely linked to increased glycolytic activity, underscoring metabolic shifts in cancer cells.
Exploration of IGF2BP2 involvement shows it is vital for TFAP2A's regulatory influence on LDHA, connecting molecular pathways to clinical outcomes.
Findings suggest potential new strategies for targeting aerobic glycolysis in pancreatic cancer treatments, though further investigation is essential.
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Xu et al. (Sat,) studied this question.
synapsesocial.com/papers/69a75f18c6e9836116a2a3df
https://doi.org/https://doi.org/10.1016/j.prp.2026.156387