ROS-triggered smart hydrogel adhesives for modulating the inflammatory microenvironment and promoting tendon-bone interface regeneration

Key Points

• Hydrogel adhesives effectively modulate the inflammatory microenvironment, enhancing regeneration at the tendon-bone interface.
• Significant improvements in tissue integration were observed with ROS-triggered hydrogel adhesives during the study.
• Assessment involved both in vitro and in vivo models to evaluate adhesive performance and healing outcomes.
• These findings support the potential of smart hydrogels in clinical applications for tendon-bone injuries.