m6A methylation dependent autophagy activation is required for anti-tumor effects of artesunate through ferroptosis in hepatocellular carcinoma

Key Points

• Artesunate induces ferroptosis in hepatocellular carcinoma, leading to significant anti-tumor effects.
• The study shows m6A methylation is crucial for activating autophagy, which contributes to killing cancer cells.
• Mechanistic analysis established the link between autophagy activation and ferroptosis in liver cancer cells.
• These findings highlight potential therapeutic pathways using artesunate and m6A modulation for liver cancer treatment.