Peripheral HLA-DR+ Neutrophils, CD163+ Monocytes and Inflammatory Serum Cytokines Coincide with Severe Immune Effector Cell-Associated Neurotoxicity at Peak Toxicity Onset in CD19 CAR T cell Therapy | Synapse
March 3, 2026
Peripheral HLA-DR+ Neutrophils, CD163+ Monocytes and Inflammatory Serum Cytokines Coincide with Severe Immune Effector Cell-Associated Neurotoxicity at Peak Toxicity Onset in CD19 CAR T cell Therapy
Key Points
Severe neurotoxicity correlates with elevated hla-dr+ neutrophils and cd163+ monocytes, indicating immune involvement.
Inflammatory serum cytokines also increase in tandem with immune cell activation during peak toxicity onset.
Assessment of immune markers provides insights into neurotoxicity mechanisms related to immune cell effects on the nervous system.
Further exploration of these associations may lead to improved monitoring and management strategies in CAR T therapy.