Biological variations in ketamine sensitivity: insights from hyperlocomotion to psychotomimetic features in genetically diverse mouse strains

Key Points

• Ketamine induces distinct hyperlocomotion behaviors, highlighting variations across genetically diverse mouse strains.
• Mice with different genetic backgrounds exhibit varied psychotomimetic features after ketamine administration, indicating biological differences.
• Observational analysis identifies specific genetic factors that influence responses to ketamine, enhancing understanding of its effects.
• Findings support the idea that genetic diversity in mice may offer insights into personalized approaches in treating conditions related to ketamine.