Impact of two different hesperidin forms loaded on nanoscale modified borate bioglass scaffolds on rat critical-sized calvarial defects

Key Points

• Bone regeneration improved significantly with the use of nanoscale bioglass scaffolds and different hesperidin forms.
• A notable increase in new bone formation was observed, reaching up to 30% at eight weeks post-surgery.
• This observational analysis evaluated critical-sized calvarial defects in a rat model, confirming the scaffolds' effectiveness.
• These findings may indicate a novel approach for enhancing bone repair, but further studies are needed for clinical application.