Comparable Endogenous Immune Reconstitution, CAR-T Expansion, and Cytokine Profiles with Bendamustine Versus Fludarabine/Cyclophosphamide Lymphodepletion | Synapse
March 3, 2026
Comparable Endogenous Immune Reconstitution, CAR-T Expansion, and Cytokine Profiles with Bendamustine Versus Fludarabine/Cyclophosphamide Lymphodepletion
Key Points
Comparable immune reconstitution and CAR-T expansion occur with both bendamustine and fludarabine/cyclophosphamide lymphodepletion.
Cytokine profiles demonstrate that bendamustine and fludarabine/cyclophosphamide produce similar cytokine activity levels during treatment.
Assessment using cytokine profiling methods across treated individuals indicates no significant advantage of one lymphodepletion method over the other.
Results highlight the need for further exploration of optimal lymphodepletion strategies in CAR-T therapies.