Refractory EBV-HLH in PTEN Hamartoma Tumor Syndrome Despite Dual Checkpoint Blockade

Key Points

• Refractory EBV-HLH was observed despite treatment efficacy with checkpoint blockade, pointing to potential resistance mechanisms involved.
• The analysis demonstrated that previous interventions failed to achieve sustained remission in the case of EBV-HLH within PTEN syndrome.
• Observation utilized case documentation to explore outcomes following dual checkpoint blockade therapy in affected individuals.
• The study highlights the complex interaction between therapy response and underlying genetic predisposition in PTEN hamartoma tumor syndrome.