Evoked emotions in anorexia nervosa: neural and behavioural correlates of social emotional processing

Previous work suggests people with anorexia nervosa (AN) display reduced facialexpression of emotion. This may influence illness progression as blunted emotionalreactions can negatively impact social relationships and increase isolation. The presentstudy aimed to replicate and further build on previous findings by examining facial andbrain responses to naturalistic, emotional films. In total, 141 women (71 AN/weight29 restored AN, 70 healthy comparison) completed two tasks in a fixed order: 1.) facial affect task and 2.) functional magnetic resonance imaging (fMRI) task. In both tasks,participants reacted to positive, neutral, and negative films, and rated their mood after each one. The effects of group and film category on facial expressions, brain responses,and mood ratings were examined. The AN group displayed reduced positive facial affectover time and lower self-reported mood in response to positive but not negative or neutral films. The fMRI task revealed no significant group differences in response to positive, neutral, or negative films. However, there was widespread activation of occipital, parietal, temporal, and frontal regions in response to the emotional films across groups.The behavioural findings replicate previously reported altered reactivity to positive filmsin AN. Additionally, task-related brain activation was observed in regions typicallyassociated with the processing of naturalistic emotional stimuli, suggesting the task was valid. However, the lack of group differences during the fMRI task raises questions about whether the behavioural differences could be related to slower warming up to the task among those with AN.