March 3, 2026Open Access

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

Key Points

Selective hepatic insulin resistance is influenced by non-enzymatic ABHD6, affecting metabolic diseases.
ABHD6 expression increases with obesity and aging, linking it to liver-related conditions.
The interaction of ABHD6 with the Akt/FoxO1 axis regulates FoxO1 activity, vital for glucose metabolism.
Potential implications indicate that targeting ABHD6 could provide new avenues for managing liver fibrosis and MASLD.

Abstract

ABHD6 expression in the liver is increased with obesity and aging.ABHD6 manipulation affects selective hepatic insulin resistance, MASLD and liver fibrosis.Non-enzymatic ABHD6 interacts with Akt/FoxO1 axis to regulate FoxO1 transcriptional activity.The effects of ABHD6 on glucose tolerance and hepatic gluconeogenesis are completely dependent on FoxO1 activity.

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

Key Points

Abstract

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