Mesenchymal stem cell-derived exosomes rescue stress-dependent morphological deficits in primary hippocampal neurons via Wnt5a/β-catenin/WAVE2 pathway

Key Points

• Exosomes derived from mesenchymal stem cells significantly rescue morphological deficits in primary hippocampal neurons, suggesting a strong therapeutic potential.
• Critical involvement of the Wnt5a/β-catenin/WAVE2 pathway was observed in alleviating stress-induced damage in neuronal structures.
• Observational analysis focused on neuronal morphology along with signaling pathways to establish the connection.
• These findings suggest a promising avenue for future treatments targeting neuronal injuries using stem cell-derived therapies.