Successful bioequivalence prediction of immediate-release vortioxetine tablets through prospective virtual crossover and parallel trials

Key Points

• Successful bioequivalence prediction indicates effectiveness of virtual trials in drug assessment.
• Using virtual crossover and parallel trials, bioequivalence metrics showed high reliability with vortioxetine tablets.
• Assessment using innovative trial designs allows for faster predictions in pharmaceutical development.
• This work may enable streamlined processes in drug approval, reducing time and costs of clinical studies.