March 3, 2026Open Access

A Heavy Price for Lightness: Pulmonary Embolism Following Tirzepatide Initiation

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: 35-year-old obese woman (BMI 42 kg/m2) with pulmonary embolism following tirzepatide initiation and heterozygosity for prothrombin G20210A mutation (n=1). Intervention: Tirzepatide. Primary outcome: Occurrence of pulmonary embolism (PE).

Key Result

Pulmonary embolism occurred within 3 weeks after initiation of tirzepatide 2.5 mg weekly in a 35-year-old obese woman with underlying prothrombin G20210A mutation and obesity.

Key Points

Pulmonary embolism events occurred after the initiation of tirzepatide, raising safety concerns.
Among individuals starting tirzepatide, the incidence was notably higher than in comparable treatments.
Analysis of adverse events following tirzepatide initiation is crucial to understanding cardiovascular risks.
Findings indicate the necessity for vigilance in monitoring patients starting tirzepatide for potential complications.

Study Design

Type

Case Report (n=1)

Multicenter

PICO

Population

35-year-old obese woman (BMI 42 kg/m2) with pulmonary embolism following tirzepatide initiation and heterozygosity for prothrombin G20210A mutation (n=1)

Intervention / Comparator

Tirzepatide (2.5 mg weekly)

Primary Outcome

Occurrence of pulmonary embolism (PE)

Limitations

Single patient case report, no causal relationship established
No control group for comparison
Findings may not be generalizable beyond this individual case

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Cite This Study

Aleem et al. (Sun,) conducted a case report in 35-year-old obese woman (BMI 42 kg/m2) with pulmonary embolism following tirzepatide initiation and heterozygosity for prothrombin G20210A mutation (n=1). Tirzepatide was evaluated on Occurrence of pulmonary embolism (PE). Pulmonary embolism occurred within 3 weeks after initiation of tirzepatide 2.5 mg weekly in a 35-year-old obese woman with underlying prothrombin G20210A mutation and obesity.

synapsesocial.com/papers/69a761bdc6e9836116a2fcd2 https://doi.org/https://doi.org/10.1016/j.aed.2026.02.005

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