Neutrophil-to-lymphocyte ratio in unresectable or metastatic esophageal squamous cell carcinoma: a systematic review, meta-analysis and meta-regression

Key Points

• Neutrophil-to-lymphocyte ratio is significantly associated with overall survival in esophageal squamous cell carcinoma.
• The analysis reveals a strong correlation between higher ratios and poorer prognosis, indicating a 1.5-fold increase in mortality risk.
• Systematic review and meta-analysis approach enhances understanding of the neutrophil-to-lymphocyte ratio's impact on patient outcomes.
• Findings highlight the need for further research to validate these results in diverse populations and clinical settings.