Delayed and Recurrent Calcineurin Inhibitor–Induced Psychosis With Agents in the Same Class and in the Absence of Supratherapeutic Levels

Key Points

• Recurrent psychosis occurred following calcineurin inhibitor treatment, emphasizing patient vulnerability.
• Key evidence identified includes both tacrolimus and cyclosporine as potential triggers for psychosis.
• The observational analysis highlights the importance of understanding drug-induced psychosis mechanisms.
• These findings suggest that improved risk stratification may help prevent psychosis in vulnerable individuals.