Pasteurella multocida toxin induces apoptosis of respiratory epithelial cells by activating the PERK–NF-κB-DR5 signaling axis

Key Points

• Apoptosis was induced in respiratory epithelial cells due to pasteurella multocida toxin exposure, facilitating cellular death and dysfunction.
• The activation of the PERK–NF-κB-DR5 signaling axis was notably significant, with DR5 upregulation observed.
• Observational analysis focused on cellular responses to pasteurella multocida toxin in respiratory epithelial cells.
• These findings highlight potential new therapeutic strategies for respiratory diseases linked to epithelial cell apoptosis.