KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression: Am J Cancer Res. 2018; 8(4): 723-731

Key Points

• KLF5 mediates the hyper-proliferative phenotype in the intestinal epithelium.
• The study focuses on mice with intestine-specific endogenous K-RasG12D expression, revealing critical interactions.
• Assessment of KLF5's role highlights its importance in gut tissue proliferation dynamics.
• Findings suggest that targeting KLF5 could be a potential therapeutic approach in intestinal cancers.