Preconditioned umbilical-cord mesenchymal stem-cell exosomes preserve functional hepatocytes in bile duct-ligated rats through alternate miRNA signaling rather than HGF signaling

Key Points

• Hepatocyte function is preserved through the action of exosomes from umbilical-cord mesenchymal stem cells.
• Key finding indicates that alternate miRNA signaling, rather than hepatocyte growth factor signaling, is involved.
• This analysis utilized bile duct-ligation in a rat model to investigate the impact on liver function.
• The findings suggest a potential new therapy for liver diseases, although further studies in humans are needed.